|The Human Glioma qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in human glioma tumor DNA. Glioma, a common primary malignant brain tumor, arises from glial cells in part due to acquired genetic alterations in cell cycle, signal transduction, transcription factors, and other genes that regulate glial cell proliferation and differentiation. Based on the primary literature and public databases, genes were chosen from the most frequently amplified or deleted genes in various forms of glioma including glioblastomas, medulloblastomas, oligodendrogliomas, pilocytic astrocytomas, and proneural gliomas. This array may serve as a useful tool to help classify glioma samples by genotype and help verify glioma phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.|
The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.